Peertechz Publications

Archives of Otolaryngology and Rhinology Case Report Abstract   Background: Buccal mucosa carcinoma represents 3 to 5% of oral-cavity cancer. Retromolar buccal trigon affected in one third of patients with buccal mucosal cancers. Squamous cell carcinoma is the commonest pathological finding. Aim: The research was designed to study suitability of submental island flap and radial forearm free flap (RFFF) as one stage reconstructive procedure after resection of large retromolar-trigonal cancers. And to assess locoregional recurrence and disease free survival after adjuvant treatment. Methods and techniques: Fifty three patients with retromolar-trigonal cancer underwent resection with safety margins, cervical block neck dissection and reconstruction with submental island flap and radial forearm free flap (RFFF) in oncology center Mansoura University from August 2010 to May 2014. Results: Seven patients underwent RFFF, 46 patients reconstructed with sub-mental flap. Partial necrosis was

Archives of Pulmonology and Respiratory Care Review Article Abstract  Abstract A multidisciplinary team approach to diagnosis and management of interstitial lung diseases (ILD) is considered gold standard and an integral part of ILD management and guidelines. The accurate diagnosis and management of individuals with ILDs poses an interesting challenge in clinical practice. This is a single center retrospective review of electronic patient letters and multidisciplinary team (MDT) records spanning a five and half year time period. In this study we assessed the accuracy of prior ILD diagnosis, the methodology used to establish a correct diagnosis and how an MDT approach to diagnosis affected subsequent management. Our results demonstrate that a multidisciplinary approach to diagnosis within a single specialist ILD center can establish a diagnosis in the majority of cases when prior diagnosis is uncertain (76%). We also show that a prior diagnosis of idiopathic pulmonary fibrosis is

Journal of Novel Physiotherapy and Physical Rehabilitation Research Article Abstract  Purpose: The purpose of this study was to establish normative values for active lumbar movement in children five, seven, nine, and 11 years of age and to find the confounding factors that affect the lumbar range. Methods: End range active flexion, extension, and right- and left-side bending of the lumbar spine were measured for 400 normally developing children (200 girls, 200 boys) using dual inclinometric technique. Means were determined for each motion by age and sex. Group relationships were explored .   http://www.peertechz.com/Novel-Physiotherapy-Physical-Rehabilitation/pdf/JNPPR-2-127.pdf 

Journal of Clinical Research and Ophthalmology Research Article Abstract Objectives: A patient's adherence to follow-up (AFU) plays a key role in the implementation of clinical research with respect to cost and validity. Most present studies focus exclusively on some specific steps during clinical research implementation, regardless of the synthetic action of patient-society-medicine system. http://www.peertechz.com/Clinical-Research-Ophthalmology/pdf/JCRO-2-123.pdf

The Journal of Civil Engineering and Environmental Sciences Research Article Abstract This paper aims to provide an innovative scenario for transportation and lowering installation of heavy caissons of 18000 tons for Persian Gulf Bridge. The project is supposed to be carried on in Bohal port from Hormozgan to Qeshm Island in Iran. There is a heated controversy over the suitable scenario to do the operation safely and lower the caissons correctly under sea to position them on their exact location.  http://www.peertechz.com/Civil-Engineering-Environmental-Sciences/pdf/JCEES-1-106.pdf

International Journal of Vascular Surgery and Medicine Clinical Image Clinical Image A 65 year old male presented to the causality department of our hospital with one day history of burning chest pain in the right upper half of the chest radiating to the right axilla & the le precordial region associated with diaphoresis. No history of fever, cough or rash was evident. Vitals were normal. An X ray chest done was normal and ECG showed RBBB (Figure 1). A Troponin T (qualitative) test along with cardiac enzymes was done in view of possible acute coronary syndrome which were noncontributory as well. e patient was given symptomatic treatment by the resident on duty but on the second day he returned back with a vesicular eruption in the upper part of the trunk on the right side which extended to the axilla and the right mammary area (Figures 2a, b). http://www.peertechz.com/Vascular-Surgery-Medicine/pdf/IJVSM-1-105.pdf

Global Journal of Infectious Diseases and Clinical Research Review Article Abstract Objective: This article presents a literature review which relates the processes, interactions, classification and the vascular and clinical characteristics of inflammation relating it with the oral cavity and describing the main cell types and chemical mediators used for its establishment. Materials and Methods: it was used as source of research the following databases: MEDLINE, LILACS, BBO, Cochrane Library, Scielo, PubMed and the database of CAPES. Results: much information was obtained concerning the chemical mediators as well as the main cell types responsible for the establishment of inflammation and its relationships with the oral cavity. http://www.peertechz.com/Infectious-Diseases/pdf/GJIDCR-1-106.pdf

Global Journal of Infectious Diseases and Clinical Research Research Article Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important pathogens that cause nosocomial infections. However, microbiological culture techniques take a few days to yield results; therefore, a simple, cost-effective, and rapid detection system is required for screening for MRSA and related bacteria: Methicillin-resistant Staphylococcus epidermidis (MRSE) carriers during the hospital admissions process. http://www.peertechz.com/Infectious-Diseases/pdf/GJIDCR-1-107.pdf

Archives of Otolaryngology and Rhinology Research Article Abstract Objective: To investigate the effects of uncorrected nasal septal deviation on the pyriform aperture (PA) dimensions, the upper anterior face height (UAFH), and the anteroposterior length of the maxilla (LM) of adult patients. http://www.peertechz.com/Otolaryngology-Rhinology/pdf/AOR-1-109.pdf

Journal of Surgery and Surgical Research Case Report Abstract Hydatid cyst is a parasitic infection of liver. One of frequent reason of liver mass is hydatid cyst in tropical and rural countries. In some cases rapidly grow up of cyst mimic liver masses. A sixty years old female admitted our hospital with abdominal pain. http://www.peertechz.com/Surgery-Surgical-Research/pdf/JSSR-1-118.pdf

Journal of Surgery and Surgical Research Case Report Introduction: Vascular compromise causes hand pain, and physical examination requires to differentiate vascular causes from isolated ulnar nerve compression. Diagnostic studies visualize vascular abnormalities such as CT scans, MRA scans, and AV fistulograms. http://www.peertechz.com/Surgery-Surgical-Research/pdf/JSSR-1-117.pdf

Journal of Vaccines and Immunology Review Article Abstract Parasites are highly prevalent in livestock worldwide and infect over one fourth of the human population also. Parasites are successful in evading host immune responses, and vaccination can prove to be an effective way to control them. However, currently very few vaccines are available against parasitic infection. http://www.peertechz.com/Vaccines-Immunology/pdf/JVI-1-111.pdf

Scientific Journal of Genetics and Gene Therapy Research Article Abstract Background: The origin of atopic disease is poly factorial and the development of atopic manifestations appears to be linked to interactions between genetic and environmental factors. Such data seem to focus attention on the rising prevalence rates of atopic dermatitis, a common debilitating skin condition in infants and young children. They also often have asthma and/or allergic rhinitis. Patients and Methods: The aim of the present study was to evaluate the rate of SPT (skin prick tests) and RAST response to Der p in atopic children with AD. We have prospectively studied 176 children (93 males and 83 females) aged from 6 months to 7 years, and divided into four different groups, including controls. We studied also their family history in the accompanying parents Results. The data of the present study show that a significantly higher proportion of children with AD have positive SPTs to Der p than the con

Peertechz Journal of Medicinal Chemistry and Research Review Article Abstract Structure activity relationship studies of 1,4-benzodiazepines have been discussed especially with their effects as antianxiety and anticonvulsants. The currently available benzodiazepines are associated with various side effects. Nowadays the purpose of these studies is to minimize side effects with these drugs. A very little alteration is possible on the benzene ring while the modification can be done on the diazepine ring. It can adopt the different conformations and in some cases some aromatic and heterocyclic rings have been fused with this part in order to see the effect of these conformation blockers on the pharmacological activity. The structure activity studies are also linked to molecular modeling studies. This is important in adding some information for the interaction of these drugs with the receptors and how this interaction can be improved. http://www.peertechz.com/Medicinal-Chemistry-Re

Journal of Surgery and Surgical Research Research Article Abstract  Background and purpose: During knee joint distraction (KJD) treatment, using an external fixation-frame, pin-tract infections frequently occur. These local skin infections, although treated successfully with oral antibiotics, might lead to latent infections. This raises concern about subsequent placement of a total knee prosthesis (TKP). This study evaluates the first five cases in which patients had to be treated with TKO after KJD failure. Patients and methods: An overall survival analysis of the first 26 patients treated with KJD revealed five failures, because of declining efficacy over time. These patients were treated with TKP. Complications of these TKPs are described and all cases were compared with age and gender matched primary-TKP-controls. WOMAC and VAS pain scores were assessed before and after TKP treatment. Results: The mean survival time of the five KJD before TKP was 61 ± 15 months (range 45-84 mon

Journal of Civil Engineering and Environmental Sciences Research Article Abstract  This paper aims to provide an innovative scenario for transportation and lowering installation of heavy caissons of 18000 tons for Persian Gulf Bridge. The project is supposed to be carried on in Bohal port from Hormozgan to Qeshm Island in Iran. There is a heated controversy over the suitable scenario to do the operation safely and lower the caissons correctly under sea to position them on their exact location. Due to this a comprehensive study is need to take heed all aspect of the operation. The study will include a discussion on both sides of installation and transportation and give a deep-rooted insight over the excuvation plane for the operation. http://www.peertechz.com/Civil-Engineering-Environmental-Sciences/pdf/JCEES-1-106.pdf

Archives of Clinical Nephrology Research Article Abstract Background: Acute renal failure (ARF) continues to be a challenging problem in critically ill patients. We reviewed the nephrology consultations in our ICU to assess the necessity of those consultations and if there are any clinical criteria to indicate a necessary consultation. Methods: Retrospective chart review of nephrology consultations for patients with ARF in our medical ICU from 2010 to 2011. After data collection we classified consultations to necessary versus unnecessary based on an experts review. We used chi square and multivariate logistic regression model to compare both groups Results: We found that 45% of patients with ARF admitted to the ICU received nephrology consultation. 32% were identified as unnecessary. Age, gender and etiology were similar in both groups. Oliguria independently predicted the need for nephrology consultation Conclusions: Oliguria predicted the need for nephrology consultation independ

Global Journal of Cancer Therapy Editorial The financial crisis has a dramatic impact on social life, since reduced or even non-existent incomes affect people’s well-being and push big parts of the population to poverty. The individuals’ financial status affects health indicators such as life expectancy, morbidity, mortality and healthcare service accessibility [1].   http://www.peertechz.com/Cancer-Therapy/pdf/GJCT-1-105.pdf 

International Journal of Vascular Surgery and Medicine Clinical Image A 65 year old male presented to the causality department of our hospital with one day history of burning chest pain in the right upper half of the chest radiating to the right axilla & the left precordial region associated with diaphoresis. No history of fever, cough or rash was evident. Vitals were normal. An X ray chest done was normal and ECG showed RBBB (Figure 1). http://www.peertechz.com/Vascular-Surgery-Medicine/pdf/IJVSM-1-105.pdf

Global Journal of Obesity, Diabetes and Metabolic Syndrome Review Article Abstract  We report clinical and molecular mechanisms relating the pro-inflammatory and antiinflammatory process in the development of the components of the metabolic syndrome, emphasizing the cardiovascular problems developed in these groups of patients, especially the Hispanic population. Namely, the incidence, component characteristics and complications of the metabolic syndrome in island Puerto Ricans are described and evidence is presented supporting the fact that the metabolic syndrome may be milder in Puerto Rico than in the mainland United States because it is characterized by less aggressive coronary artery disease and a relatively normal lipid profile. Moreover, data supports the fact that increased serum cholesterol levels produce less myocardial infarctions in Puerto Rico than in mainland Hispanics and Caucasians. In addition, the incidence of ventricular tachycardia, a complication caused by remo

Global Journal of Infectious Diseases and Clinical Research Review Article Abstract  Objective: This article presents a literature review which relates the processes, interactions, classification and the vascular and clinical characteristics of inflammation relating it with the oral cavity and describing the main cell types and chemical mediators used for its establishment. Materials and Methods: it was used as source of research the following databases: MEDLINE, LILACS, BBO, Cochrane Library, Scielo, PubMed and the database of CAPES. Results: much information was obtained concerning the chemical mediators as well as the main cell types responsible for the establishment of inflammation and its relationships with the oral cavity. http://www.peertechz.com/Infectious-Diseases/pdf/GJIDCR-1-106.pdf

Journal of Dental Problems and Solutions Research Article Abstract  The aim of the present study was to compare the dental caries status of the 12 year old children of the eastern region of Macedonia and Budgam district of Jammu and Kashmir state of India. Material and Method: In this comparative study (N=396) 12-year old children from Macedonia and 592 from India were included. Dental status of participants was evaluated using the 2013 World Health Organization caries diagnostic criteria for Decayed, Missing or Filled Teeth (DMFT) by 2 calibrated examiners in Macedonia and by the single examiner in India. Results: The mean value of the DMFT index for the whole sample of India was 1.91 ± 1.76 whereas for Macedonia it was 3.46 ± 2.90, and the difference was statistically significant (p<0.001). In the Indian sample, 152 (25.68%) and in Macedonia sample 81 (21.46%) of the individuals were caries free (DMFT=0).In both countries, the female children have higher mean DMFT values. The

Global Journal of Cancer Therapy Research Article Abstract  Eribulin sensitivity was examined in a panel of twenty-five human cancer cell lines representing a variety of tumor types, with a preponderance of breast and lung cancer cell lines. As expected, the cell lines vary in sensitivity to eribulin at clinically relevant concentrations. To identify combination drugs capable of increasing anticancer effects in patients already responsive to eribulin, as well as inducing de novo anticancer effects in non-responders, we performed a combinatorial high throughput screen to identify drugs that combine with eribulin to selectively kill tumor cells. Among other observations, we found that inhibitors of ErbB1/ErbB2 (lapatinib, BIBW-2992, erlotinib), MEK (E6201, trametinib), PI3K (BKM-120), mTOR (AZD 8055, everolimus), PI3K/mTOR (BEZ 235), and a BCL2 family antagonist (ABT-263) show combinatorial activity with eribulin. In addition, antagonistic pairings with other agents, such as a topois

Journal of Addiction Medicine and Therapeutic Science Case Report Abstract Background: Tramadol induced disorder is a new problem. Objective: To explain the efficacy of low dose of clonidine, baclofen and ibuprofen (NSAID) in the treatment of severe and chronic tramadol dependency (2000 mg daily). Method: To evaluate the usefulness of non-narcotic drugs in the management of severe tramadol withdrawal symptoms. Results: Clonidine 0.3 mg, baclofen75 mg and ibuprofen 1200 mg per day is very effective in the management of severe tramadol withdrawal symptoms and craving. Discussion: Our findings indicates that low dose of clonidine, baclofen and ibuprofen (NSAID) is beneficial in the treatment of severe tramadol dependency. This is a fascinating result. Conclusion: To our knowledge dramatic effects combination of clonidine, baclofen and ibuprofen in these situations has not been published yet, and this finding is a considerable addition to the literature.    http://www.peertechz.com/A

Archives of Community Medicine & Public Health Research Article Abstract  Background: In the past two decades negative attitudes towards vaccination has surfaced among parents. These concerns are related to safety, adverse effects, lifestyle and religious issues. The present study focuses on compensatory health beliefs (CHB), the beliefs that the adverse consequences of one health behavior are compensated by another health behavior, and examines whether CHB predicts behavior and mediates the association between the intention to vaccinate one’s children and vaccination behavior. Methods: Parents (n=90) to children up to 6 years old filled an online questionnaire taping intentions and behaviors to vaccinate, self-efficacy to vaccinate, compensatory health beliefs related to vaccination and lifestyle. Results: A significant negative association was found between CHB and intention to vaccinate and vaccination behavior (r=-0.69, p<.01), and a non-significant positive association

International Journal of Immunotherapy and Cancer Research Research Article Abstract  Background: VEGF is involved in cancer development by stimulating neo-angiogenesis and tumor proliferation. Anti-angiogenic therapies, especially tyrosine kinase inhibitors such as sunitinib, have significantly improved cancer prognosis. Nevertheless, renal side effects, such as proteinuria and thrombotic microangiopathy, have been reported. The underlying physiopathological mechanisms remain unclear, but animal models and clinical similarities with preeclampsia suggest that such therapies affect the function of the endothelial and epithelial layers of the glomerular basement membrane, with activation of the endothelin signaling system and loss of glomerular slit diaphragm integrity. The aim of this in vitro study was to determine sunitinib effects on normal podocytes and glomerular endothelial cells. Methods: The glomerular microvascular endothelial (GMVEC) and human glomerular visceral epithelia

Journal of Surgery and Surgical Research Research Article Summary  Indroduction: Neuroendocrine tumors (NEN) of the gastro-entero-pancreatic tract (GEP) are a group in themselves very heterogeneous of tumors that are different for the site of localization in the digestive tract (foregut, midgut and hindgut), both in relation to the pathological aspects, functional activity and nosographic classification. Materials and methods. In the period from January 2001 to July 2006 (III Clinical Surgery unit) and from January 2006 to October 2013 (Surgery of the Digestive Tract Unit), UOCS of the University Hospital of Catania has come to our observation 4 patients in the first period and six in the second period. Cases of NEN-GEP we observed allow to highlight how there are elements of clinical differences that make it difficult framing them. Results: Are summarized personal pathologic and therapeutic results. Discussion: The interest in the subject stems also from the fact that tumors NEN /

Journal of Surgery and Surgical Research Research Article Abstract Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer. Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2. Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study. Conclusion: Male breast cancer is a rare disease with a poor prognosis despite the recent increase in i

Journal of Surgery and Surgical Research Case Report Abstract  Abstract Cystic Echinococcosis (CE) is a zoonotic infection caused by larval form of the parasite Echinococcus granulosus. The adult tapeworm inhabit the small intestine of some carnivores (called definitive or final hosts), and the larval phase, or “metacestode” develops in the herbivores (intermediate hosts). The presentation form of the larval phase is the development of cysts, called hydatid cysts. Although all of us know the vital cycle of the parasite and the different aspects of the disease, the designations around the parasite, its evolution and some therapeutic procedures is not uniform. In fact we frequently see the use of inappropriate terms, based on incorrect concepts. It would be useful to use the same nomenclature and it is absolutely necessary that the nomenclature is correct and universally accepted. So, it is pertinent to remember some important points related to the CE and, above all, to clarify some

Journal of Civil Engineering and Environmental Sciences Research Article Abstract  Cultural barrier is always perceived as the prime challenge for modernizing idle construction markets. Unsurprisingly, most changes in construction hinge on understanding the benefits of sustainable transformation. Persistent attempts in stagnant construction cultures have materialized in some noted changes. Successful sustainable transformation in such economies appears to be chiefly impeded at the execution level. The Kotter’s model for change is globally accepted approach for comprehensive implementation of major business transformations. Modern organizational change initiatives typically embrace the notions of Six Sigma in a broader sense. This concept paper propose the use of Six Sigma DMAIC technique for reforming stagnant construction cultures. A case study from a challenged construction market is referred to for potential implication.    http://www.peertechz.com/Civil-Engineering-Environmen

Journal of Cardiovascular Medicine and Cardiology Research Article Abstract  Background: Autonomic nerve innervation pathway from the ventricular GP to the pulmonary veins (PV) remains unclear. Aim: This study investigates the autonomic innervations from aortic root ventricular GP to the PVs. Nissl’s staining and fluorescent dual label staining were performed to determine the neuron structure in the aortic root GP in five dogs. Avidin Biotin Complex (ABC) staining were performed to study the efferent autonomic pathway from the aortic root GP to the PVs. Results: Adrenergic and cholinergic neurons were both present in the aortic root GP, with the majorities were cholinergic. ABC positive nerve fibers that contained both cholinergic and adrenergic neurotransmitters penetrated directly from the aortic root GP to the left PVs. Conclusion: Autonomic innervation of the Left PVs is partly originated from the aortic root ventricular GP .  http: //www. peertechz. com/Cardiovascular-Medici

Journal of Dental Problems and Solutions Case Report Abstract Rehabilitation of lost dental aesthetic is one of the most important concerns for contemporary dentistry. Conservative treatment modality along with aesthetic approaches, such as direct and indirect laminate veneer restorations were the treatment of choice. Laminate veneers are restorations to correct aesthetic deficiencies and discolorations. Direct laminate veneers involve the application of a composite material directly to the prepared tooth surface. This case report discusses the composite mirroring using direct composite laminate veneer technique application to the re-established the aesthetic problems related to discolorations in anterior region . http: //www. peertechz. com/Dental-Problems-Solutions/ pdf/JDPS-2-116.pdf

Global Journal of Medical and Clinical Case Reports Case Report Introduction  Coarctation of the aorta is a relatively common defect that accounts for 5-8% of all congenital heart defects and is characterized by discrete medial thickening with superimposed neointimal tissue, leading to aortic lumen narrowing of different degrees.  www. peertechz. com/Clinical-Case-Reports/pdf/ GJMCCR-2-119.pdf

International Journal of Oral and Craniofacial Science Research Article Abstract  Introduction: Nasal obstruction is a risk factor in sleep-disordered breathing with a negative impact on the quality of life in humans Objective: In this study we determined whether histological development of olfactory bulb development could be influenced by an early temporary (3 d) nasal obstruction associated with physiological state. Methods: The rats were killed at specific time points after surgery. Plasma samples were taken for biochemical analyses, and histological measurements were performed. Shortly after nasal obstruction, the volumes of external plexiform (CPE), internal plexiform (CGI), and granule cell (CGr) was measured in both sexes of test rats compared with controls. Results and Conclusion: Reversible nasal obstruction was further associated with reduced dimensions of the volumes of CPE (male: 55%; female: 37%), CGI (male: 49%; female: 34%) and CGr (male: 70%; female: 47%). Basal cor

Archives of Renal Diseases and Management Research Article Abstract Peyronie’s disease is a relatively common condition, with an incidence of 3-9%. It is often associated with diabetes and erectile dysfunction (ED). This condition causes a penile deformity that can affect sexual penetration and lead to psychological disorders because of the difficulty in coping with the situation. Sometime the surgery does not satisfy the patients; we tried to evaluate this aspect of the disease. Materials and methods: We treated 46 patients for recurvatum penis secondary to Peyronie’s disease. The clinical examination involved an accurate medical history, a physical examination to identify the plaque, ultrasonography to detect calcified plaque, and a photograph of the erect penis to document the recurvatum and sandglass deformity. In the case of ED, we administered the IIEF-5 and performed intracavernous injection of PGE1; in patients eligible for grafting, we also carried out a dynamic echo colou

Global Journal of Infectious Diseases and Clinical Research Research Article Abstract  Increasing isolation of multidrug-resistant Acinetobacter baumannii (MDR) has been reported in worldwide and it is recently one of the most difficult nosocomial acquired gram-negative pathogens to control and treatment. These bacteria are one of ESBL producing that great potential have for the rapid development of antibiotic resistance. Use of medicinal herbaceous drugs recommended for treatment since ancient periods. Humans have been used and realize their beneficial effects. With the increase in population and urban growth, reduced use of synthetic drugs, many of these of medicinal herbs have been replaced. Because of Satureja, Origanum vulgare and Thyme essence has antimicrobial properties so can be used against infections caused by MDR Acinetobacter baumannii. In this study the antimicrobial effects of Satureja, Origanum vulgare and Thyme essence on drug-resistant strains of Acinetobacter bau

Archives of Depression and Anxiety Case Report Abstract Eating Disorders are a heterogeneous group of complex psychiatric disorders that affect physical and psychological functioning, thus compromising life itself. They are often characterized by extreme preoccupation with food, caloric intake and expenditure as well as bodily weight and shape. Additionally, individuals present several forms of recurrent compulsive behavior, such as frequent weighting, body checking, and eating rituals. In many cases food consumption is considered a” failure” and its presence in the body “harmful and even “toxic” leading the individual to adopt a wide variety of purging behaviors in order to achieve a state of mental and physical “cleanliness” Two cases of compulsive bowel emptying, one suffering from Anorexia Nervosa and one suffering from Bulimia Nervosa, are presented. The compulsive bowel emptying behavior compromised of repeated and/or prolonged voluntary tension of the abdominal and pelvic mus

Peertechz Journal of Environmental Science and Toxicology Research Article Abstract  Background and Aim: Niger delta environment has been exposed to organic and inorganic contaminants from industries and domestic wastes, thereby enhancing the capacity of the ecosystem into harboring a sizeable population of microorganisms. Most of these microorganisms are found in the water column, bottom sediment and water film, resulting in their elevated levels in seafood. Proper understanding of the transfer of microorganisms through the food web is essential to predict the exposure of seafood consumers to possible health consequences associated with its consumption in the coastal areas. Hence, the present study examines the microbial content of some sea foods such as: periwinkle (Tympanotonus fuscatus); mudskipper (Periophthalmus papilio); mullets (Liza falcipinis) Oyster (Crassotrea gasar) and water from Ekerekana and Buguma creeks, in the Niger delta, Nigeria. Methods: Seasonal variations in

International Journal of Radiology and Radiation Oncology Research Article Abstract  Various techniques are used in image-guided radiotherapy (IGRT). Cone beam computed tomography (CBCT) is widely used in IGRT on linear accelerators. The increased accuracy of IGRT enables reducing planning target volume margins and doses to normal tissues. However, for radiation therapies requiring fractionated irradiation, increased exposure dose attributed to CBCT becomes problematic. We investigated the smallest projection angle required to provide target accuracy for CBCT of lymph nodes located above or below the collarbone in breast cancer patients. Phantom and clinical experiments were conducted on the basis of shifts obtained through gray value-based auto-image registration performed using 360° CBCT. Corrected images obtained from decreasing projection angles in 10° increments were compared with a single 360° image. In the phantom and clinical experiments, the smallest projection angle

International Journal of Aquaculture and Fishery Sciences Research Article Abstract Background and Aim: The intensive nature of aquaculture has subjected fish to a number of stressors in the culture medium, anesthetics are widely used to minimize the issue of stress during farming operations and activities. Clove oil is a well known, established and acceptable anesthetics commonly used in aquaculture, this anesthetics is not readily available in developing countries, thus leaving the fish farmers with option of using the locally available plant extracts as anesthetic agent in fish culture. This study therefore assessed the efficacy of aqueous extracts of clove seed and its effect on hematological parameters of the fish. Methods: A total of 300 Clarias gariepinus comprises of 150 juveniles and 150 adult fish were exposed in triplicates to aqueous extracts of clove seed at concentrations of 5.0, 10.0, 15.0, 20.0 and 25.0mg/l at the rate of 10 fish per tank for both juveniles and ad

Journal of Vaccines and Immunology Review Article Abstract Parasites are highly prevalent in livestock worldwide and infect over one fourth of the human population also. Parasites are successful in evading host immune responses, and vaccination can prove to be an effective way to control them. However, currently very few vaccines are available against parasitic infection. Two important limitations in the emergence of effective parasitic vaccines are incomplete understanding of the immunoregulatory pathways involved in immunity, and the lack of precise information regarding host-pathogen interactions. Precise identification of parasite genes and the role of their products in parasite biology may assist in the identification of useful antigens, which could then be produced in recombinant systems. Many recombinant parasitic antigens have been successfully used in livestock and new vaccines are under trail. Numerous vaccine antigens are defined to target a wide range of parasite spec

Global Journal of Infectious Diseases and Clinical Research Research Article Abstract Background: Pivmecillinam has good pharmacokinetic properties for treatment of infections in the urinary tract, and the mecillinam resistance rate in Enterobacteriaceae is very low. In a European guideline pivmecillinam is recommended as a first-line drug for treatment of lower urinary tract infections. In Danish and Norwegian guidelines pivmecillinam is also recommended for acute uncomplicated pyelonephritis, although with very sparse documentation of effect. Objectives: We intended to investigate the therapeutic outcome of pivmecillinam treatment of uncomplicated pyelonephritis caused by Enterobacteriaceae treated by general practitioners (GP’s) in primary care. Material and methods: We included patients clinically diagnosed with pyelonephritis at the GP, urine samples positive for Enterobacteriaceae and empirical treatment with pivmecillinam. We intended to include patients prospectively, but

Archives of Otolaryngology and Rhinology Case Report Abstract Importance: Surgicel is an effective hemostat either for intra or post-operative bleedings, but should be used cautiously in the case of tonsillectomy. Some surgeons choose to leave pieces of surgicel in the tonsils bed for a continuous haemostatic effect. The material when left in the tonsils fossa is no different than other foreign body and put the patient in a significant risk of suffocation. Observations: four years old girl was admitted to the E.R with multiple complaints and rapid deterioration of her physical state few days after tonsillectomy. Bulky Haemostatic Material spheres almost completely blocked the oropharynx. The foreign material was removed and the complaints resolved, with full recovery. Conclusions and Relevance: leaving surgicel impactions in the oropharynx upon completion of tonsillectomy operation should be avoided. http: //www. peertechz. com/Otolaryngology-Rhinology/p df/AOR-1-108.pdf

International Journal of Dermatology and Clinical Research Review Article Abstract Vitiligo and melasma are acquired pigmentary disorder of the skin and also the leading cause for dermatologist consultation in South Asian countries like Nepal. Vitiligo vulgaris and melasma are common examples for depigmentary and hyperpigmentary conditions respectively. There are multiple proven medical, surgical and combined modalities of managing them but the challenge in our part of the world with majority of Fitzpatrick skin types III-V is; it remains a psychosocial-cosmetic disease. http: //www. peertechz. com/Dermatology-Clinical-Resea rch/pdf/IJDCR-1-110.pdf

International Journal of Agricultural Science and Food Technology Research Article Abstract Background and Aim: Fish plays a crucial role in human nutrition and food supply across the globe, particularly among the poor segment of the society. Food fish currently represents the major source of animal protein needed for growth and development, especially among the children and women who are more vulnerable to malnutrition in developing countries. The importance of food to an individual and society cannot be over emphasized, as food is a basic necessity of life and sufficient intake of quality food is imperative for people to live a strong, vibrant and productive life. Considering the importance of fish food, this study therefore assessed the contribution of brackish water fish farming to stable fish supply and food security in coastal communities of Rivers State. Methods: The roles of brackish water aquaculture in fish supply and food security in 10 coastal communities of Rivers St

International Journal of Veterinary Science and Research Case Report Abstract Hemangiosarcoma (HSA) is a common and highly metastatic tumor that affects predominantly large-breed dogs. The median survival time for dogs diagnosed with splenic HSA without adjuvant chemotherapy after surgery is 86 days. Fenofibrate is an FDA-approved drug commonly utilized to treat high cholesterol and high triglyceride levels in humans. However, fenofibrate has also been shown to possess anti-proliferative and anti-metastatic properties against several aggressive and highly metastatic tumors in vitro and in small animal models. We report a case of a 6.5-year-old dog diagnosed with a splenic hemangiosarcoma and treated solely with micronized fenofibrate, administered orally once a day following splenectomy. The dog survived for over 26 months (804 days) after initial diagnosis without signs of adverse effects due to fenofibrate treatment. http: //www. peertechz. com/Veterinary-Science-Researc h/pd

Global Journal of Anesthesiology Editorial Editorial Oxygen consumption increases with increased alveolar ventilation and respiratory alkalosis occurs. Thus, PaCO2 becomes 28-32 mmHg in pregnant women, and this amount is compensated with renal bicarbonate absorption. Preoxygenation can be made slower by inhalation of 100% oxygen for 2-5 minutes. Denitrogenation of the lungs occurs after three minutes [1]. Another method can be applied quickly with 4-8 deep breaths of 100% oxygen [2]. However, for pregnant women who will have a cesarean section under general anesthesia, an oxygen fraction of 1 has been shown to increase fetal oxygenation more compared with the 0.3 or 0.5 FiO2 [3]. As this may lead to free oxygen radicals and apsorbtion atalectesia, 80 % oxygen is recommended. http: //www. peertechz. com/Anesthesiology/pdf/GJA-2-1 16.pdf

Global Journal of Anesthesiology Editorial Editorial Open surgery and fetoscopic surgery are of the safest procedures, whilst the ex-utero intrapartum treatment (EXIT) procedure has lost its significance as a result of the severe complications experienced both by the mother and the fetus. While uteroplacental circulation maintains, the EXIT is performed before delivery. The fetus is to be delivered at the conclusion of the case. A neonatal resuscitation area and two operating rooms are needed. Significant uterine relaxation is required for open midge station surgery. The risk for rapid bleeding and hemodynamic instability are the common accompanying parts of this procedure. It still continues to be a process done in certain centers not only in United States but also in Europe [1]. http: //www. peertechz. com/Anesthesiology/pdf/GJA-2-1 17.pdf

Global Journal of Anesthesiology Editorial In dental practice, intravenous general anesthesia is useful for patients who are difficult to treat when not sedated such as those with neurological disorders [1]. http: //www. peertechz. com/Anesthesiology/pdf/GJA-2-1 18.pdf

Journal of Surgery and Surgical Research Research Article Summary Introduction: The appearance of a framework for occlusive colorectal tumor raises complex issues and difficult. We need to ensure a resumption of normal bowel function in patients often in extreme conditions. Emergency surgery flounders in a derivation and a resection with restoration of intestinal transit. The progress of digestive endoscopy can now make available a medical procedure can solve the framework occlusive both as palliation both as a bridge to safer surgery. The purpose of this study is to evaluate the indications and limitations of the method of colon prosthesis with selfexpandable stents. http: //www. peertechz. com/Surgery-Surgical-Research/ pdf/JSSR-1-112.pdf

Archives of Otolaryngology and Rhinology Review Article Abstract Introduction: The loss of laryngeal voice after total laryngectomy can have an impact on the quality of life and communication of affected individuals. Postoperative phonatory methods may promote advantages in oral communication and reduce the functional, organic and emotional changes experienced by the patients. On this basis, the objective of the present study was to review the literature in order to determine the impact on the quality of life of total laryngectomees according to the form of rehabilitation chosen after the procedure and to identify the protocols most frequently used to assess the quality of life of these individuals. http: //www. peertechz. com/Otolaryngology-Rhinology/p df/AOR-1-107.pdf

International Journal of Radiology and Radiation Oncology Research Article Abstract Introduction: Brachytherapy is a preferred choice of radiotherapy in the treatment of sensitive tissues cancer like intestine and gonad. The treatment is expensive because of the frequent replacement of radionuclide sources. A better understanding of cell killing and the cellular responses at different dose rates, might aid in tumor cell killing with fewer doses thereby enhancing a better prognosis. Methods: The cervix cancer cell line was irradiated with doses ranging from 2Gy-10 Gy at three different dose-rates as used in brachytherapy along with unexposed sample as control. The biological effects of different doses and dose rate of the cells was assessed by measuring its cytotoxicity, genotoxicity and clonogenic ability of exposed cells. The bystander effect was examined by coculturing the exposed tumor cells with the unexposed normal blood lymphocyte and vice-versa. Results: A significant and

Archives of Clinical Hypertension Research Article Abstract Introduction: Hypertension is the most common chronic non-contagious disease. High blood pressure is an important risk factor for premature mortality and contributes to the development of heart disease, stroke and kidney failure. In spite of the fact that it is consider to be an adult disease, the frequency in young people has increased. Methods: All students enrolled in first, second and third semester of the Medical School, Faculty of Medical Sciences – Universidad Central del Ecuador, period October 2014 - March 2015 were invited to participate. Body mass index was calculated; waist circumference and blood pressure were measured. The diagnosis of hypertension was made using recommended criteria by the ATP III, IDF and JNC 7. Blood chemistry including urea, glucose, creatinine, uric acid and lipid profile were determined. Results: 883 college students in a range of 17-25 years were included; the average age was 19.3 ±

Archives of Clinical Gastroenterology Case Report Abstract Tuberculosis is described during the use of monoclonal antibodies against tumour necrosis factor (TNF) for Crohn’s disease treatment. We report a case of a 44 year old man that developed fever, night sweats and weight loss during immunosuppressive and anti-TNF therapy for Crohn’s disease . After extensive investigation we performed mediastinoscopy with biopsy of the paratracheal lymph node. A histopathological study revealed caseous necrosis. The patient improved after therapy against tuberculosis. During anti-TNF therapy, the diagnosis of tuberculosis may be mainly difficult when an atypical location is present. Clinical skills are important mainly in countries where tuberculosis is endemic. http: //www. peertechz. com/Clinical-Gastroenterology/ pdf/ACG-1-108.pdf

Peertechz Journal of Cytology and Pathology Review Article Bone is metabolically active organ where 10% of it is normally and constantly replaced. Bone constitutes the trabecular or spongy bone (25%) and cortical or compact bone (75%). Trabecular bone is metabolically active and forms the internal supportive elements of the bone. The outer capsule is made up of cortical bone and is particularly present in the shafts of long bones. At the structural level, two different forms of bone can be distinguished, i.e. cortical or compact bone− which forms the diaphysis of long bones and provides protection for the medullary cavity− and trabecular, cancellous, or spongy bone, which is found at the ends of the long bones (epiphyses). The total skeleton comprises about 20% of trabecular bone. Trabecular bone has a porosity of 50%– 90%, while cortical bone of 10% [1]. http: //www. peertechz. com/Cytology-Pathology/pdf/PJC P-1-102.pdf

Journal of Vaccines and Immunology Research Article Abstract  Background: Pneumococcal disease is an infection caused by a bacterium called Streptococcus pneumonia which can lead to life-threatening invasive pneumococcal diseases. In the UK, pneumococcal vaccination is targeted at those most at risk of serious disease: infants, older people and those with risk factors. It has been proposed that PPV23 be co-administered with influenza vaccine during seasonal vaccination to maximize uptake. This study aimed to estimate 1) the UK prevalence of pneumococcal risk co-morbidities 2) corresponding pneumococcal vaccine administration rates 3) rates of vaccination co-administration and 4) frequency of pneumococcal revaccination. Methods: To gather evidence on current vaccination practice in the UK and to quantify the rates of co-administration of influenza and pneumococcal vaccination, data was collected from general practices in the Royal College of General Practitioners sentinel surveill

International Journal of Immunotherapy and Cancer Research Review Article Abstract Probiotics are a class of symbiotic bacteria whose administration in adequate amount provides health benefits to the host by altering the composition of gut microbiota. The gut microbiota is known to regulate both the host immune system and metabolism, leading to increased bone mass by inhibiting bone resorption. Ovariectomy induced estrogen deficiency which mimics postmenopausal osteoporosis in women leads to enhanced bone inflammation and resorption. Recently it has been reported that different strains of bacteria (e.g. Lactobacillus, Bifidobacteria etc.), have important role in gut-bone regulation in ovariectomized mouse. Thus administration of probiotics can open up new avenues in treatment of various inflammatory bone conditions such as osteoporosis and rheumatoid arthritis by modulating the delicate balance between the gut microbiota and immune system. http: //www. peertechz. com/Immunother

International Journal of Clinical Endocrinology and Metabolism Review Article Abstract C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inh

International Journal of Clinical Endocrinology and Metabolism Research Article Abstract Purpose: Recently, there have been an increasing number of studies indicating that Florine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a sensitive method in the evaluation of thyroid cancer. This retrospective study aims to assess the value of FDG PET/CT in the evaluation of thyroid cancer and determine the association between serum thyroglobulin (Tg) levels and FDG PET/CT. Methods: We reviewed FDG PET/CT images of 104 patients with differentiated thyroid cancer (DTC) (28 men, 76 women) whose: (1) iodine-131 (131I) whole-body scanning (WBS) was negative but had elevated Tg levels or (2) Tg level was low, but showed abnormal findings using various imaging methods. Results: The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG PET/CT findings were found to be 95.92%, 87.27%, 87.04%

International Journal of Clinical Endocrinology and Metabolism Case Report Abstract We present a 40 year old lady who was previously reviewed in a different center with a neck swelling and a clinical and biochemical picture of post-partum thyroiditis. She underwent a fineneedle aspiration (FNA) biopsy of a hypoechoic isthmus nodule that was reported as being a follicular neoplasm and diagnostic surgery was recommended. She presented to ourselves for a second opinion. She had clinically improved by this time and on re-do sonography was found to have multiple lymph nodes in close proximity to the isthmus and prominent appearances of thyroiditis, but no suspicious thyroid nodules per se. Follow-up ultrasonography revealed unchanged appearances and on review at the regional thyroid nodule and cancer multi-disciplinary meeting an unanimous consensus was reached that no invasive procedures or treatments were indicated apart from clinical and sonographic monitoring. The likely original

Archives of Depression and Anxiety Mini Review Abstract Major depressive disorder (MDD) is a leading cause of morbidity and mortality, and it is a common psychological disorder in the world. Present antidepressants modulate monoamine systems directly or indirectly, because MDD is classically considered as a neurochemical disease, in which monoamine systems are perturbed including serotonin, noradrenaline or dopamine systems. However, recent evidences suggest that MDD is associated with the impairments of synaptic plasticity or cellular resilience to stress. Cellular resilience is maintained by mitochondria with the supplying cellular fuel or ATP. In addition, it is suggested that mitochondrial functions in neurons influence synaptic plasticity. Therefore, impairment of mitochondrial function can be the cause of the MDD. The present review article summarizes the recent evidences about the association between mitochondrial impairment and MDD, and it suggests that improvement of mit

Journal of Novel Physiotherapy and Physical Rehabilitation Case Report Abstract Introduction: Patients with severe traumatic brain injury are known to have poor outcomes. The prognosis is even worse if they remain vegetative or minimally conscious for months. The objective of this case report is to highlight the novel use of optokinetic chart stimulation to improve muscle strength and functional mobility in a patient who was in a vegetative state of unconsciousness for months after sustaining a severe traumatic brain injury and C7 spinal fracture. The patient could not open their eyes and breathed through a tracheostomy tube. Methodology: An optokinetic chart was moved in front of the patient: from side to side, up and down and finally forwards and backwards. This was supplemented with sensory interaction for balance once the patient could stand with assistance. Results: Oxford score improved from absent voluntary movements to 410/410 within one month after treatment had begun. G