HER2 Status in Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and Review of the Literature
Journal of Surgery and Surgical Research
Research Article
Abstract
Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer. Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2. Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study. Conclusion: Male breast cancer is a rare disease with a poor prognosis despite the recent increase in incidence in recent years. The diagnosis is often delayed and injuries are treated in advanced stages.
http://www.peertechz.com/Surgery-Surgical-Research/pdf/JSSR-1-113.pdf
Research Article
Abstract
Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer. Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2. Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study. Conclusion: Male breast cancer is a rare disease with a poor prognosis despite the recent increase in incidence in recent years. The diagnosis is often delayed and injuries are treated in advanced stages.
http://www.peertechz.com/Surgery-Surgical-Research/pdf/JSSR-1-113.pdf
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