The Value of Positron Emission Tomography/Computerized Tomography Imaging in the Restaging of Differentiated Thyroid Cancers and Evaluation of its Association with Thyroglobulin Levels
International Journal of Clinical Endocrinology and Metabolism
Research Article
Abstract
Purpose: Recently, there have been an increasing number of studies indicating that Florine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a sensitive method in the evaluation of thyroid cancer. This retrospective study aims to assess the value of FDG PET/CT in the evaluation of thyroid cancer and determine the association between serum thyroglobulin (Tg) levels and FDG PET/CT. Methods: We reviewed FDG PET/CT images of 104 patients with differentiated thyroid cancer (DTC) (28 men, 76 women) whose: (1) iodine-131 (131I) whole-body scanning (WBS) was negative but had elevated Tg levels or (2) Tg level was low, but showed abnormal findings using various imaging methods. Results: The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG PET/CT findings were found to be 95.92%, 87.27%, 87.04%, 96.00%, and 91.35%, respectively. The best Tg cut-off value was found to be 10.4 ng/ml. In the Tg level <10.4 ng/ml group, the sensitivity, specificity, PPV, NPV, and accuracy of FDG PET/CT were found to be 94.12%, 91.30%, 88.89%, 95.45%, and 92.50%, respectively. In the Tg level ≥10.4 ng/ ml group, sensitivity, specificity, PPV, NPV, and accuracy of FDG PET/CT exams were found to be 96.88%, 84.38%, 86.11%, 96.43%, and 90.63%, respectively.
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Research Article
Abstract
Purpose: Recently, there have been an increasing number of studies indicating that Florine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a sensitive method in the evaluation of thyroid cancer. This retrospective study aims to assess the value of FDG PET/CT in the evaluation of thyroid cancer and determine the association between serum thyroglobulin (Tg) levels and FDG PET/CT. Methods: We reviewed FDG PET/CT images of 104 patients with differentiated thyroid cancer (DTC) (28 men, 76 women) whose: (1) iodine-131 (131I) whole-body scanning (WBS) was negative but had elevated Tg levels or (2) Tg level was low, but showed abnormal findings using various imaging methods. Results: The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG PET/CT findings were found to be 95.92%, 87.27%, 87.04%, 96.00%, and 91.35%, respectively. The best Tg cut-off value was found to be 10.4 ng/ml. In the Tg level <10.4 ng/ml group, the sensitivity, specificity, PPV, NPV, and accuracy of FDG PET/CT were found to be 94.12%, 91.30%, 88.89%, 95.45%, and 92.50%, respectively. In the Tg level ≥10.4 ng/ ml group, sensitivity, specificity, PPV, NPV, and accuracy of FDG PET/CT exams were found to be 96.88%, 84.38%, 86.11%, 96.43%, and 90.63%, respectively.
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