Physiology of Spinal Opioids and its relevance for Pain Management Selection

Open Journal of Pain Medicine
Review Article
To use spinal opioids appropriately, it is necessary to understand the pharmacokinetics and clinical pharmacology of these drugs including which opioids produce selective spinal analgesia and which do not. Briefly, spinal selectivity is highest for hydrophilic opioids and lowest for lipophilic opioids....

https://www.peertechz.com/articles/physiology-of-spinal-opioids-and-its-relevance-for-pain-management-selection.pdf

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