Tetrahydrobiopterin Concentrations in Normal and Coronary Artery Diseased Heart Tissue

Journal of Cardiovascular Medicine and Cardiology
Research Article
Background: Tetrahydrobiopterin (BH4) is a cofactor that plays a major role in cardiovascular health and disease. BH4 levels in the human heart have not been previously reported.
Objective and Methods: Using a novel LC-MS/MS method we measured BH4 and BH2 levels in human heart tissue from subjects with (n=19) and without (n=19) coronary artery disease (CAD).
http://www.peertechz.com/Cardiovascular-Medicine-Cardiology/pdf/JCMC-3-123.pdf

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