Risks of Methadone use as Substitute Therapy for Opioid Addiction during Pregnancy and use of Clonidine as a Plausible Alternative

Journal of Addiction Medicine and Therapeutic Science
Review Article
Detoxification of opioid addiction during the pregnancy has been avoided since 1970 after some reports showed untoward outcome including stillbirth and acute narcotic withdrawal syndrome in neonates. It was recommended at that time to avoid detoxification until more data was collected and improved monitoring of fetal homeostasis became available.
http://www.peertechz.com/Addiction-Medicine-Therapeutic-Science/pdf/JAMTS-2-113.pdf

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