Mediastinal Tuberculosis Lymphadenitis during Anti-TNF Therapy - Case Report


Archives of Clinical Gastroenterology

 Case Report

Abstract
Tuberculosis is described during the use of monoclonal antibodies against tumour necrosis factor (TNF) for Crohn’s disease treatment. We report a case of a 44 year old man that developed fever, night sweats and weight loss during immunosuppressive and anti-TNF therapy for Crohn’s disease . After extensive investigation we performed mediastinoscopy with biopsy of the paratracheal lymph node. A histopathological study revealed caseous necrosis. The patient improved after therapy against tuberculosis. During anti-TNF therapy, the diagnosis of tuberculosis may be mainly difficult when an atypical location is present. Clinical skills are important mainly in countries where tuberculosis is endemic.


http://www.peertechz.com/Clinical-Gastroenterology/pdf/ACG-1-108.pdf

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