Blood Catalase Activities, Catalase Gene Polymorphisms and Acatalasemia Mutations in Hungarian Patients with Diabetes Mellitus

Global Journal of Obesity, Diabetes and Metabolic Syndrome
Review Article
Abstract 
Introduction: Catalase decomposes hydrogen peroxide into oxygen and water. Its low concentration could be involved in signaling while its high concentration is toxic. Aim: This short review discusses the association of blood catalase and diabetes mellitus in Hungarian diabetic patients. Results: Several cohort studies showed decreased blood catalase activity in type 2 diabetes and in gestational diabetes. Among the catalase gene polymorphisms rs769217 showed a weak association with type 1 diabetes. Regarding rs1001179 polymorphism patients with TT genotype have a risk for lower life expectancy.
http://www.peertechz.com/Obesity-Diabetes-Metabolic-Syndrome/pdf/GJODMS-3-111.pdf

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