International Journal of Pharmaceutical Sciences and Developmental Research

Research Article

 

A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine

Background: The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-methyl transferase (TPMT), the enzyme associated with 6-MP metabolism, as a pharmacogenomics biomarker.

http://www.peertechz.com/Pharmaceutical-Sciences-Developmental-Research/IJPSDR-1-102.php

 

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