Global Journal of Obesity, Diabetes and Metabolic Syndrome



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Review Article

The Interaction between Metabolic Disease and Ageing


Signalling pathways associated with caloric excess and caloric restriction. The interaction between the signalling molecules associated with longevity and their activation or inhibition by exposure to either excess or insufficient calories demonstrates the close links between metabolism and ageing. Key: AMP = adenosine monophosphate; ATP = Adenosine triphosphate IGF = insulin-like growth factor; IRS = insulin receptor substrate; AKT = protein kinase B; mTor = mammalian target of rapamycin; NAD = nicotinamide adenine dinucleotide; PGC-1α = Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; s6K1 = ribosomal protein S6 kinase beta-1; PPAR = peroxisome proliferator-activated receptor.

http://www.peertechz.com/Obesity-Diabetes-Metabolic-Syndrome/GJODMS-1-101.php 

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