Pathological Biomineralization in the Calcific Aortic Valve

Journal of Cardiovascular Medicine and Cardiology
Editorial
The prevalence of moderate to severe calcific aortic valve stenosis in patients ≥75 years old is 2.8% and only 40% of patients with surgical indication undergo aortic valve replacement because of high perioperative risk, older age, lack of symptoms, and patient/family refusal [1]. In the absence of hemodynamically significant left ventricular (LV) outflow obstruction, calcific aortic valve disease (CAVD) prevalence raises up to 25% in patients aged from 65 to 74 years old [2,3] and independently predicts cardiovascular (CV) event, overall and CV mortality. As the population ages and CAVD incidence and prevalence increase, it is crucial a deeper understanding of the patho-physiology of heart valve calcification that could provide novel insight into medical therapeutic approaches to delay or modify the disease course.
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http://www.peertechz.com/Cardiovascular-Medicine-Cardiology/JCMC-3-132.php

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